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Notably, bi-allelic MC4R mutation carriers had long-term outcomes as poor as those with bi-allelic LEPR or POMC mutations, suggesting that biallelic mutations in LMP genes generally lead to more severe impairment of surgical efficacy compared to heterozygous mutations

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Baudouin C, Labb A, Liang H, Pauly A, Brignole-Baudouin F

10.1093/jxb/ery096 J