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In patients with renal dysfunction, refractory hypotension, severe metabolic abnormalities, active seizure, or persistent coma, extracorporeal removal by haemodialysis or haemofiltration may be considered, although there are no controlled trials that demonstrate an improvement in outcome with these measures [8890]
Chem Biol Interact 314
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The recommended dosage is 2 to 5 grams per day, and can be taken at any time but is usually suggested 30 to 60 minutes before exercise
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