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Cytochrome P450 3A (CYP3A) is the primary enzyme responsible for orforglipron metabolism, with minor contributions from other CYP isoforms
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While some users report modest weight loss (a few pounds over months), others saw no change on the scale despite feeling slightly less hungry
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A number of other studies have also suggested that chronic stress causes atrophy of the PFC and hippocampus owing to glucocorticoid imbalance (McEwen et al., 2012)
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