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Vitamin B6 Why it matters: Vitamin B6 is a cofactor in more than 140 reactions, including those that regulate protein, fat, and glucose metabolism

Any findings referenced are derived from experimental models and controlled research settings and should not be interpreted as therapeutic or clinical outcomes

In STZ-induced diabetic mice, proximal tubule specific knockout of phosphofurin acidic cluster sorting protein 2 (PACS-2) gene severely impaired reticulophagy of tubular cells and aggravates kidney injury

Furthermore, its ability to modulate cellular functions makes it a viable candidate for targeted drug delivery systems

Symptoms include fatigue, weakness, and shortness of breath

Rather than functioning as independent mechanisms, HSPs, autophagy, mitophagy, the UPS, ERAD, and UPR collectively form a multilayered, compensatory system that preserves protein quality and cellular viability