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Improved mitochondrial efficiency has been observed, but prolonged caloric restriction may reduce mitochondrial biogenesis and oxidative capacity, compromising muscle function even if absolute mass loss is modest [35]
(Varney has done paid speaking gigs for Eli Lilly.) The tactic of taking a GLP-1 shot less frequently, meanwhile, hasnt been tested in a large randomized clinical trial
A recent study showed that combining PPIs with GLP-1 medications was associated with more upper GI side effects
Concurrent medications: Certain medications may interact with or compound Ozempic's effects