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While it helps regulate energy balance and can mimic the effects of caloric restriction(1), it is a complex molecule to manage

When Madeson shared his data with Knudsen in 1995, she realised that it rang a bell because she had noticed that both normal and obese rates experienced a lasting and reversible weight loss when given one of her early GLP-1 analogues

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More recently, GLP-1s have been designed to target obesity, too

These risks are heightened by limited long-term safety data and a lack of standardized dosing protocols