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Bisphosphonates, denosumab, and calcium supplementation all target the resorption side of the equation

According to the National Institutes of Health's Office of Dietary Supplements, even at high doses, vitamin B12 is considered safe since the body doesn't store excess amounts of it

Which approach is better depends entirely on your situation, goals, and what you plan to do after the medication stops

For use as a supplemental source of vitamin B12 in cattle, horses, sheep, and swine

Some report minor weight changes, but those are often linked to improved appetite from previously undernourished participants rather than targeted fat reduction

Higher doses have inconsistent effects and, in some cases, reduced cell proliferation