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Concomitant use of weight-promoting medications, such as insulin or sulfonylureas, may further blunt the weight loss effects of GLP-1 RAs [45]

They typically contain reactive functional groups, such as amines, thiols, or carboxyls, which allow selective linkage between different molecules for targeted drug delivery, fluorescent labeling, or functional modifications

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Fasting plasma glucose decreased by 16.2 mg/dL, compared to 9.0 mg/dL with placebo

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