Unlike sermorelin, which indirectly encourages GH release, ipamorelin directly prods the pituitary gland into action
27 and Supplementary Figs
Patients with polycystic ovary syndrome (PCOS) may experience indirect benefits from tirzepatide through weight reduction and subsequent improvements in insulin resistance, though this is not an FDA-approved indication and specific studies in this population remain limited
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For men specifically, the visceral fat reduction advantage of tirzepatide is particularly relevant
For patients with obesity and comorbidities (type 2 diabetes, hypertension, sleep apnea), referral to obesity medicine specialists or registered dietitians is appropriate for comprehensive management