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Switching medications might be an option, but it's not always the first or best step

In mice models, B1 cells are shown to produce IgM (natural antibody), which are anti-inflammatory, whereas B2 cells seen in VAT produce IgG that are pathogenic cells associated with obesity-associated inflammation (100)

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The reduction in body weight also corresponds to improvements in metabolic parameters such as waist circumference and body mass index (BMI) [8]

For big splotches that appear or ones that spread all over, she recommends seeing your primary care doctor or health care provider right away

Acknowledgements This study has been delivered through the NIHR Manchester Biomedical Research Centre (BRC) (NIHR203308)