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By reversibly binding glucokinase (GK), GCKR modulates GKs localization and enzymatic activity, serving as both a metabolic sensor and a safeguard against excessive glucose flux (94)
Liraglutide was associated with a 0.23 percentage point decline in HbA1c ( P = .017), a 52.6 mg/g drop in urine albumin-to-creatine ratio ( P = .007) and a 0.25 mmol/L reduction in LDL cholesterol ( P = .02) from drug initiation to 1 year
This figure shows that the proportion of patients achieving any particular level of improvement was consistently higher for divalproex sodium than for placebo
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