NICE Clinical Knowledge Summaries recommend B12 injections for: Pernicious anaemia an autoimmune condition affecting intrinsic factor production Malabsorption syndromes including coeliac disease and inflammatory bowel disease Post-surgical states particularly following gastrectomy or ileal resection Strict vegan diets when oral supplementation proves inadequate, though oral cyanocobalamin is usually sufficient for dietary deficiency Clinical trials demonstrate that B12 injections rapidly improve haematological parameters and neurological symptoms when deficiency is confirmed through blood tests
Treat any solution prepared in an organic vehicle as short-lived and non-sterile
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[2] Risk factors may occur possibly more in elderly people due to impaired intestinal absorption, and in children, premenopausal women, and pregnant women, whose diets are low in animal foods
The agency evaluates characterization, safety, available effectiveness evidence, and historical use under the regulatory criteria