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Because the brain can neither synthesize glucose nor store more than a few minutes supply in the form of glycogen, it is critically important that a steady glucose supply be available to brain cells via the circulation
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Observed side effects in research settings are generally mild and may include temporary nausea-related observations, flushing-related observations, headache-related observations, fatigue-related observations, administration-site irritation, pigmentation variability, pigmentation variability involving freckles or moles, and temporary appetite-related response variability depending on research amount, UV exposure, administration frequency, skin type, and individual physiological sensitivity