Under-Eating or Inadequate Protein When calorie intake drops too low, or when protein intake is insufficient, the body may shift into a more energy-conserving state
9,10 The mechanism of the relationship is poorly understood, with hypotheses including that a drop in blood sugar can lead to a rise in VEGF expression 11,12 and that systemic glycemic changes can correspond with glucose concentration in the vitreous, and in turn lead to retinal injury
Alternatives include other GLP-1 receptor agonists (such as dulaglutide or liraglutide), SGLT2 inhibitors (such as dapagliflozin or empagliflozin), DPP-4 inhibitors, or insulin therapy
(3) Risk in a Danish population was similarly elevated in the year following a high measurement
However, it does mean mass-marketed compounded tirzepatide copies face much tighter legal limits
Scientific Reports, 12 (1), 1-9