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The short answer is yeswith proper medical supervision, these medication classes can coexistbut individual factors matter significantly, and your prescriber must know your complete medication history

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NE from sympathetic nerves passes into the intestinal lumen We used a Ussing chamber to investigate whether the NE concentration on the mucosal side of the cecal tissue was increased by administration of drugs to the serosal side

10.1038/jcbfm.2012.151 101 MartinK.JacksonC