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Liver is the major site of HDL synthesis and interestingly NADP + correlated positively with liver markers alanine transaminase (ALT), aspartate transferase (AST) and gamma-glutamyl cysteine (Fig
Incorporating fiber-rich foods, such as fruits, vegetables, whole grains, and legumes, can help maintain bowel regularity and prevent constipation
This translated into real outcomes in the SELECT trial , where semaglutide reduced heart attacks, strokes and cardiovascular deaths by around 20% in people with established heart disease without diabetes
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Potential cognitive benefits under investigation: Improved learning and memory consolidation Enhanced neuroplasticity and synaptic function Reduced accumulation of pathological proteins (amyloid-beta, tau) Protection against vascular damage affecting brain tissue Clinical trials exploring GLP-1 receptor agonists for Alzheimer's disease and other neurodegenerative conditions are ongoing, but evidence in humans remains inconclusive and mixed
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