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Key Insight: With no energy improvements by week 4, bloodwork can help assess whether NNMT is being effectively inhibited

Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin [PMID: 12842127] Laboratory literature summary: Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II

Stav D, Raz M

p38 upregulates E3 ligases (Atrogin-1, MuRF1, Nedd4) and autophagy genes (Atg7), while JNK phosphorylates c-Jun and FoxO to enhance their pro-atrophic activity (Vainshtein and Sandri, 2020)

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& Secor, W