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Maintenance ketamine treatment for depression: a systematic review of efficacy, safety, and tolerability

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The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

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Dunnetts post hoc test and one-way ANOVA tests were used to compare inhibitory effects on IGF-1 DES-mediated changes in fEPSP slopes [2]