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The WHO December 2025 guideline and what it means for BMI thresholds In December 2025, the World Health Organization released its first-ever guideline on the use of GLP-1 therapies for treating obesity in adults

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It is essential to keep a realistic perspective about the rate of weight loss that you can achieve

adolescents with obesity have a prediabetes glycemic profile (9, 10), with ~35% progressing to persistent dysglycemia or overt diabetes during adulthood (11)

This is the mechanistic basis for the "additive rather than redundant" framing the two pathways meet at the mitochondrial output but enter the regulatory web at different upstream points

Phase 2 clinical trial data published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023) demonstrated that retatrutide produced substantial reductions in body weight up to approximately 24% over 48 weeks at the highest dose studied (12 mg once weekly) in adults with obesity alongside meaningful improvements in glycaemic control and cardiometabolic markers