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Total RNA was extracted using the TaqMan Reverse Transcription kit (Thermo Fisher Scientific)

It is provided in a stable, lyophilized format suitable for mass spectrometry calibration and cell-free binding studies

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Although the overall frequency of liver enzyme elevations across the over 1,400 participant safety databases of danuglipron was in-line with approved agents in the class, the spokesperson explained, this single asymptomatic participant in one of the dose-optimization studies was sufficient to scrap development of the GLP-1 agonist