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Steady dose escalation to higher doses than for glycaemic control are indicated if: BMI is 30 kg/m 2 , or BMI 27 to 30 kg/m 2 , and for the range 2730 kg/m 2 if there is one weight-related comorbidity (hypertension, dyslipidaemia, cardiovascular disease, obstructive sleep apnoea, prediabetes or T2D

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This duration of safety monitoring provides meaningful reassurance about sustained exposure effects that would not be apparent in brief trials

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No official human dosing standard exists, so doses should be set with a physician

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The nanospheres were characterized through transmission electron microscopy (TEM), energy-dispersive X-ray analysis (EDX), and powder X-ray diffraction (XRD)

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