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A growing body of evidence demonstrates that the tumor microenvironment, including cancer-associated fibroblasts (CAFs), can modulate drug sensitivity in tumor cells

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While these oral options remove the "injection barrier" and are likely to increase patient demand, they are priced similarly to injectable versions and are not expected to reduce unit costs for plans

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Berberine GI side effects in clinical trials affect 10 to 35% of users, with diarrhea reported specifically in 15 to 25% of those taking 1000 to 1500mg daily