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A large cardiovascular outcomes trial is ongoing and expected to provide important long-term safety insights, with results anticipated around 2027

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Rotating injection sites (e.g., abdomen, thighs, upper arms) is crucial to prevent localized skin irritation, tissue damage, or the formation of lumps (lipohypertrophy)

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86 Importantly, recent studies have shown that the chemokine receptor CXCR4 is highly expressed in exhausted CD8 and regulates CD4 T cells

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