The information and data Lilly has provided to FDA demonstrate that Lillys supply is currently meeting or exceeding demand for these drug products, and that Lilly has developed reserves that it now holds in its finished product inventory, plus significant units of semi-finished product, and has scheduled substantial additional production over the coming months, such that supply will meet or exceed projected demand, the agency wrote
While semaglutide does slow gastric emptying, there is limited evidence that this leads to clinically significant nutrient malabsorption in most patients
For someone taking exogenous GLP-1 medication, this is largely irrelevant because the synthetic version overwhelms natural production anyway
This mutation causes the PCD (Seth et al., 1999)
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For example: In the SURMOUNT-1 trial, participants taking tirzepatide lost up to 22.5% of body weight over 72 weeks