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Preclinical research summary The main evidence includes: (1) studies in tendons that link BPC-157 with cell growth, survival and migration [1]
[ref] A review study found that BPC 157 counteracted thrombosis, including deep vein thrombosis, and also counteracted heart arrhythmias and infarctions
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BPC-157 is a 15-residue, 1419.53 g/mol pentadecapeptide whose mechanistic literature centres on local angiogenic signalling, Hsieh and colleagues (J Mol Med, 2017) reported upregulation and internalisation of VEGFR2 in human endothelial cells, and Chang and colleagues (J Appl Physiol, 2011) reported increased FAK and paxillin phosphorylation with greater outgrowth and migration in cultured rat tendon fibroblasts
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