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found that anti-PD-1, alone or in combination with anti-CTLA-4, failed to inhibit tumor growth in mice receiving a standard diet, whereas KD implementation, or oral administration of 3-hydroxybutyrate (3-HB), a principal KB generated in the KD, reestablished therapeutic responses

Because the stria vascularis and spiral ganglion cells operate under continuous bioelectric strain, they are highly susceptible to oxidative injury

If this balance is disrupted, it can lead to copper overload and zinc deficiency

One manages the "power grid" (NAD+), while the other manages the "waste disposal and security system" (glutathione)

Activation of the UPR generally serves as a readout for ER stress, but it is not clear what diminished ER stress implies in terms of an actual accumulation of unfolded proteins, particularly because some stressors, such as palmitate loading, activate the UPR apparently independent of the protein folding process (Volmer et al., 2013)