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Its unclear if 5-amino-1MQ, by lowering NNMT, affects these cancers.

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Parameters reported in animal studies are specific to those study designs and are not validated for human use

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A 2025 European Journal of Clinical Nutrition commentary on the NICE guideline argued that the diagnostic threshold and clinical awareness still need to be tightened further, especially around pernicious anaemia, which is still under-recognised in primary care