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From topical research: Most commonly reported observation: mild transient redness at application site (attributed to vascular activity from VEGF stimulation) No systemic adverse events reported in human topical studies at standard concentrations No evidence of carcinogenicity or mutagenicity in available in vitro models From injectable research (preclinical): At supratherapeutic doses in animal models, mild injection site reactions have been noted No organ toxicity observed in standard preclinical safety panels No immunogenicity concerns identified (consistent with its endogenous structure) Copper considerations: GHK-Cu delivers a small amount of bioavailable copper

doi: 10.1016/j.bbabio.2012.02.024 61 KarapetyanN

Interplay between Inflammation and pathological bone resorption: insights into recent mechanisms and pathways in related diseases for future perspectives

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Human Reproduction, 18, 19281932 Thomson, R.L., Brinkworth, G.D., Noakes, M