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De Palo E, Gatti R, De Palo C, et al
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4b) that is secreted from K cells in the mucosa of the duodenum and jejunum and which also exerts its actions through a G protein-coupled receptor
Its possible that different mechanisms may be at play
A longer half-life might allow the drug to work for a longer time
Its primary actions include: Inhibiting the reuptake of dopamine and noradrenaline in the central nervous system Minimal effect on serotonin pathways, distinguishing it from most other antidepressants Potential appetite suppression as a secondary effect, though this is not its primary indication Reducing nicotine cravings through dopaminergic pathways Bupropion is metabolised primarily in the liver by the CYP2B6 enzyme system, producing active metabolites
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