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Given its role in modulating D2 receptor signaling, inhibition of PDE10A has shown promise in attenuating the hyperdopaminergic activity associated with the positive symptoms of schizophrenia, such as delusions and hallucinations (Grauer et al., 2009

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Structure alignment The Go structures 6g79, 6oik, and 6k41 were aligned using the PyMOL v2.3 (pymol.org)

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It is essential, however, to label this correctly: this is a mechanistic argument supported by short-term endocrine data, not a demonstrated long-term safety or efficacy advantage