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In a study conducted by Ju et al., a novel series of substituted indole arylidene analogs incorporating structural motifs from ascidians, with balanced COX-1/COX-2 inhibition, was introduced (108)
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It was designed to mimic the fat-burning effects of hGH without triggering its growth-related or insulin-modulating side effects
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As expected GPP3 was observed bound within the hydrophobic pocket of VP1, in an essentially identical conformation to that previously observed for this compound bound to plant expressed PV3-SC8 18 (Fig