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In hepatocytes, GLP-1 inhibits intracellular lipid production through the cAMP/AMPK signaling pathway, and this pathway can act directly upon LXR (Henquin, 2000)
doi: 10.1007/s11947-014-1391-x 67 NairD
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10.3389/fcell.2021.696684 76 MicheliL.D'AndreaG.CeccarelliM.FerriA.ScardigliR.TironeF
Nausea, vomiting, constipation, and reduced appetite are common during dose escalation and typically improve within 12 weeks at each new dose
1 50% sustained eGFR decline occurred in 165 patients (9.3%) on Ozempic and 213 patients (12.1%) on placebo
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