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The 2.4% A1C reduction observed at higher doses in diabetic participants exceeds both Semaglutide and Tirzepatide
Notably, a marginal increase in risk (RR 1.34, 95% CI 1.04, 1.72) was observed in studies with methodological flaws 41
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Thus, M1 is important for the LC3B interaction, while M3 and M4/M5 modulate the WIPI2 interaction
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