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Yang Y, He L, Liu P, et al

Traditional weight loss interventions like very-low-calorie diets, behavioral modification programs, and over-the-counter supplements have a substantially weaker evidence base than prescription GLP-1 medications for sustained, clinically significant weight loss that persists beyond the active intervention period - a distinction that matters when you're evaluating whether a monthly subscription to a medication program is a better long-term value than another round of a protocol you've already tried and discontinued

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Ideal program candidates: Have a Body Mass Index (BMI) of 27 or higher for those with comorbidities (such as hypertension, type 2 diabetes and sleep apnea), or 30 or higher for those without comorbidities