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The Novo Nordisk Canada Wegovy consumer information notes that nausea, vomiting, and diarrhea can cause dehydration and says drinking fluids is important, especially for people with kidney problems

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The safety profile of orforglipron has been similar to other incretin-based therapies

For someone using semaglutide for weight management, the appetite suppression weakens

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It binds pituitary GHRH receptors to drive a pulsatile release of growth hormone , which in turn raises IGF-1