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Current evidence suggests that any metabolic rate reduction during GLP-1 treatment is primarily due to weight loss itself, rather than a direct drug effect
Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs
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This is not a theoretical concern
Id describe myself as Skin Type 1 My protocol was as follows
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