Clinical studies show that long-term use is generally safe when monitored by a healthcare professional
Importantly, these efficacy results were seen with very low rates of clinically significant hypoglycemia and a safety and tolerability profile consistent with the GLP-1 receptor agonist class. Study design For the phase 3 trial, Frias and colleagues analyzed data from 1,879 adults with type 2 diabetes inadequately controlled with metformin therapy of at least 1,500 mg daily (mean age, 57 years
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Fmoc deprotection step was initiated by adding 0.75 mL of pyrrolidine/DMF (17% v/v) directly to the undrained post-coupling solution (optimization experiments were performed by adding 0.75 mL of 11.325% v/v pyrrolidine/DMF as described in Table 1)