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Pharmacological inhibition of MAOB in PTSD-like mice model (MAOB-inhibitor drug therapy) To evaluate whether pharmacological inhibition of MAOB could reverse PTSD-related symptoms, we utilized KDS2010 36 , a potent, selective, and reversible MAOB inhibitor

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In contrast to the lack of brain entry of dopamine in vivo [68], our results with the targeted dopamine-nanoformulation using the BBB model combined with midbrain organoids indicate that the nanoformulation may help dopamine to reach the brain tissue after BBB penetration