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In a Phase 3 clinical trial Orforglipron demonstrated superior glycaemic control compared with Dapagliflozin, with a tolerability profile consistent with the GLP-1 receptor agonist class, including increased rates of discontinuation due to adverse events, positioning it as a potential effective oral treatment option for type 2 diabetes

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82 UA was observed to reduce reactive oxygen species (ROS) and interleukin-6 (IL-6) production in macrophages while enhancing fatty acid oxidation (FAO) under inflammatory and hypoxic conditions in vitro