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Provided a framework for what to look for, where to start and where to hope to end up

Study characteristics The main characteristics of included studies are summarized in Supplementary Table 1

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Results vary by individual, but many patients in a physician-supervised program lose between 5 and 15 percent of their starting body weight over the course of treatment

Many patients, particularly those with sensitive GI systems, experience severe nausea, vomiting, or body aches even at the lowest standard dose

NAD+ is probably the most important co-factor for improving mitochondrial function