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baseline Ipamorelin (Via GHS-R1a): Ghrelin receptor agonism in the pituitary/hypothalamus Synergy with GHRH: potentiates GH release 3-5x Somatostatin Inhibition (GHIH): Tonic Unlocking Pulse frequency: Physiological periodicity maintenance Selectivity: no cortisol effects (vs GHRP-2/6) Combined Pharmacokinetics: GH Liberation Profile: Pico GH: 90-120 minutes post combination administration Magnitude: 5-10x baseline levels (dose-dependent) Lift duration: 4-6 hours Secondary IGF-1: sustained increase 24-48h Applications, Mechanisms, and Extended Research 1

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We thank Sondra Turjeman for critical editing of the manuscript