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The 15mg vial best suits researchers running early SURMOUNT-style escalation cohorts (2.5mg/week through 7.5mg/week), a single-dose pilot at the peak 15mg/week SURMOUNT-1 dose, or initial protocol-testing work before scaling to the 30mg format
The administrative system is not built for that scale
In pivotal phase 3 trials, orforglipron produced weight loss in the range of approximately 7 to 9 percent from baseline at the doses studied over the trial period, with the agent also demonstrating improvements in cardiometabolic parameters including blood pressure and lipid indices
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