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In 1986 they first documented a reduced incretin effect in patients with type 2 diabetes ( Diabetologia 29:4652), and then in 1993 they demonstrated that, in patients with poorly controlled type 2 diabetes, a single exogenous infusion of an incretin (GLP-1) increased insulin levels in a glucose-dependent manner and normalised fasting hyperglycaemia ( Diabetologia 36:741744)
Trends Biotechnol, 2014
Effects on quality of life, major adverse CV events & mortality are likely limited or uncertain. November 2025 Pdf of factsheet : Semaglutide binds to, and activates, the GLP-1 (glucagon-like peptide-1) receptor to increase insulin secretion, suppress glucagon secretion, and slow gastric emptying
(2025, April 24)
Correct dosage is crucial for this peptide therapy
Additionally, because all participants had obesity (BMI 30 kg/m2), the findings may not generalize to individuals with AUD without obesity
