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However, in a large study involving people with diabetes who had no comorbidities, GLP-1 RAs were not shown to increase the risk of developing pancreatitis at any time point up through 5 years of use.[ref][ref][ref][ref] The Cleveland Clinic now counsels that GLP-1 RA patients should be screened for pancreatitis risk factors, and a lower dose should be used to reduce the risk of pancreatitis.[ref] Related article : Pancreatitis and Genetic Risk Factors Gastroparesis: Case reports tie semaglutide to a risk of gastroparesis (very slow stomach emptying)

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This reduction may result in symptoms such as fatigue, lackluster skin, increased vulnerability to illnesses, and slower recovery times

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Kidney and Thyroid Concerns: Certain GLP-1 drugs may impact kidney function and thyroid health, with some studies indicating a potential risk of thyroid tumors. Another significant side effect of prescription GLP-1 medications, such as semaglutide and tirzepatide, is the potential loss of muscle tone