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The GLP-1 CVD outcome trials a) Elixa (Lexisenatide) b) Leader (Liraglutide) c) Sustain-6 (Semaglutide) d) Exscel (Weekly Exenatide) e) Harmony (Albiglutide) f) Rewind (Dulaglutide) g) Pioneer 6 (Oral Semaglutide) Elixa Study (Evaluation of Lixisenatide) In ELIXA, the investigational GLP-1 receptor agonist, lixisenatide, neither reduced nor increased cardiovascular events compared with placebo
Nemours Childrens Health
Fineman, M
Theres biological rationale that GLP-1 RAs may have neuroprotective effects (they reduce inflammation, improve insulin signaling in the brain, etc.)
The increase in Ca 2+ is mediated by IP3 induced release of intracellular Ca 2+ and by depolarization leading to activation of voltage dependent Ca 2+ channels
