MCFA freely enter hepatocytes and are oxidized to acetyl-CoA, regardless of the ATP demand of the cell
Unfortunately, they also make long-term weight loss extremely difficult and are a major reason people experience weight regain after dieting
At higher concentrations, it competes with the unfolding protein for water molecules, increasing the energy required for the protein to unfold and thereby keeping it in its active configuration
Prolonged exposure to light can also degrade GLP-1 medications, which is why they are supplied in opaque or light-protective packaging
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We do NOT prescribe GLP-1 for patients with a personal or family history of medullary thyroid cancer or MEN2, history of pancreatitis, type 1 diabetes, or during pregnancy/breastfeeding