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Abstract Purpose of review The primary objective of this article is to conduct an in-depth exploration of the most recent advancements in incretin-based pharmacological interventions for obesity management, specifically focusing on glucagon-like peptide-1 (GLP-1) and the dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonists
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Whether they ever will depends less on the receptor, whose biology is no longer in serious doubt, than on two engineering problems that the recent failures have brought into focus: getting the compound to the right neurons, and getting the right patients into the trial
A minority may have lingering mild symptoms beyond 4 weeks
PARP inhibitors as therapeutics: beyond modulation of PARylation
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