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These CVOT findings are supported by a real-world study performed in over 3 million patients with T2DM from the United States, in which patients treated with SGLT2is did not have a higher risk of any or lower amputation compared with incretins or other glucose-lowering agents [77]

Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity

Improves energy levels, supports red blood cell production, and aids in neurological function

Coverage requires BMI 30 or 27 with comorbidities and documentation of prior lifestyle modification attempts

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