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Namely, it is always applied alone (Sikiric et al., 1993
Mechanism of Action FOXO4-DRI disrupts the protective interaction between FOXO4 and p53 in senescent cells , allowing damaged cells to undergo apoptosis
These short half-life values emphasize curcumins rapid metabolism and elimination, contributing to its limited systemic bioavailability and therapeutic efficacy after oral intake (117)
This approach may suit people who do not respond well to oral supplementation or standard glutathione supplements
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This is deeply connected to citrate availability, since citrate is a cataplerotic compound in TCA cycle, which derives from oxaloacetate and acetyl-CoA, but it can also be deviated to feed other metabolic pathways [60, 61]
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