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As glutathione increased both infectious zoospore production and host resistance to zoospore infection, our study suggests that this antioxidant may play an important role in the host/pathogen interaction during chytridiomycosis
The study indicates that intranasal administration (i.n.) may be a more effective mode of administration against cerebral ischemia as Ex-4 could be transported across the BBB by fast anterograde axonal transport
Subsequent studies confirmed senolytic activity in additional cell types including chondrocytes, Leydig cells, keloid fibroblasts, and endothelial cells demonstrating that the FOXO4-p53 dependency is a conserved feature across multiple senescent cell populations